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VISITAS

INFORMACIÓN REGULATORIA  DE ACCESO AL TRATAMIENTO

  • Ficha Técnica, Informe Público Europeo de Evaluación (EPAR) y Prospecto de Soliris en la web de la Agencia Europea de Medicamentos (EMA):

DOCUMENTO PDF

  • Información para los profesionales sanitarios sobre Soliris en el tratamiento del SHUa:

https://www.ema.europa.eu/en/medicines/human/EPAR/soliris

  • Información para los pacientes y  sus cuidadores sobre Soliris en el tratamiento del SHUa:

https://cima.aemps.es/cima/publico/detalle.html?nregistro=07393001

  • Informe de evaluación y recomendaciones del NICE de eculizumab en el tratamiento del SHUa:

https://www.nice.org.uk/guidance/hst1/resources/eculizumab-for-treating-atypical-haemolytic-uraemic-syndrome-pdf-1394895848389

Publicaciones:

Diseases of complement dysregulation-an overview.

Wong EKS, Kavanagh D.

Semin Immunopathol. 2018 Jan;40(1):49-64. doi: 10.1007/s00281-017-0663-8. Epub 2018 Jan 11. Review.

PMID: 29327071 [PubMed - in process] Free PMC Article

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Purtscher-Like Retinopathy Associated with Atypical Hemolytic Uremic Syndrome.

Ustaoğlu M, Önder F, Solmaz N, Öztürk S, Ayer M.

Turk J Ophthalmol. 2017 Dec;47(6):348-350. doi: 10.4274/tjo.66502. Epub 2017 Dec 25.

PMID: 29326853 [PubMed] Free PMC Article

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Atypical hemolytic-uremic syndrome due to complement factor I mutation.

Almalki AH, Sadagah LF, Qureshi M, Maghrabi H, Algain A, Alsaeed A.

World J Nephrol. 2017 Nov 6;6(6):243-250. doi: 10.5527/wjn.v6.i6.243.

PMID: 29226095 [PubMed] Free PMC Article

Atypical Hemolytic Uremic Syndrome: A Brief Review.

Zhang K, Lu Y, Harley KT, Tran MH.

Hematol Rep. 2017 Jun 1;9(2):7053. doi: 10.4081/hr.2017.7053. eCollection 2017 Jun 1. Review.

PMID: 28626544 [PubMed] Free PMC Article

Eculizumab in secondary atypical haemolytic uraemic syndrome.

Cavero T, Rabasco C, López A, Román E, Ávila A, Sevillano Á, Huerta A, Rojas-Rivera J, Fuentes C, Blasco M, Jarque A, García A, Mendizabal S, Gavela E, Macía M, Quintana LF, María Romera A, Borrego J, Arjona E, Espinosa M, Portolés J, Gracia-Iguacel C, González-Parra E, Aljama P, Morales E, Cao M, Rodríguez de Córdoba S, Praga M.

Nephrol Dial Transplant. 2017 Mar 1;32(3):466-474. doi: 10.1093/ndt/gfw453.

PMID: 28339660 [PubMed - indexed for MEDLINE] Free PMC Article

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Case report - atypical hemolytic uremic syndrome triggered by influenza B.

Kobbe R, Schild R, Christner M, Oh J, Loos S, Kemper MJ.

BMC Nephrol. 2017 Mar 20;18(1):96. doi: 10.1186/s12882-017-0512-y.

PMID: 28320387 [PubMed - indexed for MEDLINE] Free PMC Article

An innovative and collaborative partnership between patients with rare disease and industry-supported registries: the Global aHUS Registry.

Woodward L, Johnson S, Walle JV, Beck J, Gasteyger C, Licht C, Ariceta G; aHUS Registry SAB.

Orphanet J Rare Dis. 2016 Nov 21;11(1):154. Review.

PMID: 27871301 [PubMed - indexed for MEDLINE] Free PMC Article

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Clinical evaluation of thrombotic microangiopathy: identification of patients with suspected atypical hemolytic uremic syndrome.

Shen YM.

Thromb J. 2016 Oct 4;14(Suppl 1):19. eCollection 2016. Review.

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Clinical Practice Guidelines for the Management of Atypical Hemolytic Uremic Syndrome in Korea.

Cheong HI, Jo SK, Yoon SS, Cho H, Kim JS, Kim YO, Koo JR, Park Y, Park YS, Shin JI, Yoo KH, Oh D.

J Korean Med Sci. 2016 Oct;31(10):1516-28. doi: 10.3346/jkms.2016.31.10.1516.

PMID: 27550478 [PubMed - indexed for MEDLINE] Free PMC Article

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Genetic Atypical Hemolytic-Uremic Syndrome.

Noris M, Bresin E, Mele C, Remuzzi G.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors.

GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.

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Terminal Complement Inhibitor Eculizumab in Adult Patients With Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label Trial.

Fakhouri F, Hourmant M, Campistol JM, Cataland SR, Espinosa M, Gaber AO, Menne J, Minetti EE, Provôt F, Rondeau E, Ruggenenti P, Weekers LE, Ogawa M, Bedrosian CL, Legendre CM.

Am J Kidney Dis. 2016 Jul;68(1):84-93. doi: 10.1053/j.ajkd.2015.12.034. Epub 2016 Mar 21.

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Improved renal recovery in patients with atypical hemolytic uremic syndrome following rapid initiation of eculizumab treatment.

Walle JV, Delmas Y, Ardissino G, Wang J, Kincaid JF, Haller H.

J Nephrol. 2017 Feb;30(1):127-134. doi: 10.1007/s40620-016-0288-3. Epub 2016 Mar 19.

PMID: 26995002 [PubMed - indexed for MEDLINE] Free PMC Article

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Recovery of renal function after long-term dialysis and resolution of cardiomyopathy in a patient with aHUS receiving eculizumab.

Emirova K, Volokhina E, Tolstova E, van den Heuvel B.

BMJ Case Rep. 2016 Feb 15;2016. pii: bcr2015213928. doi: 10.1136/bcr-2015-213928. Erratum in: BMJ Case Rep. 2016;2016. pii: bcr2015213928corr1. doi: 10.1136/bcr-2015-213928corr1.

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Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome.

Greenbaum LA, Fila M, Ardissino G, Al-Akash SI, Evans J, Henning P, Lieberman KV, Maringhini S, Pape L, Rees L, van de Kar NC, Vande Walle J, Ogawa M, Bedrosian CL, Licht C.

Kidney Int. 2016 Mar;89(3):701-11. doi: 10.1016/j.kint.2015.11.026. Epub 2016 Jan 28.

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The global aHUS registry: methodology and initial patient characteristics.

Licht C, Ardissino G, Ariceta G, Cohen D, Cole JA, Gasteyger C, Greenbaum LA, Johnson S, Ogawa M, Schaefer F, Vande Walle J, Frémeaux-Bacchi V.

BMC Nephrol. 2015 Dec 10;16:207. doi: 10.1186/s12882-015-0195-1.

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An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document.

Campistol JM, Arias M, Ariceta G, Blasco M, Espinosa L, Espinosa M, Grinyó JM, Macía M, Mendizábal S, Praga M, Román E, Torra R, Valdés F, Vilalta R, Rodríguez de Córdoba S.

Nefrologia. 2015;35(5):421-47. doi: 10.1016/j.nefro.2015.07.005. Epub 2015 Oct 9. English, Spanish.

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Advances and challenges in the management of complement-mediated thrombotic microangiopathies.

Davin JC, van de Kar NC.

Ther Adv Hematol. 2015 Aug;6(4):171-85. doi: 10.1177/2040620715577613. Review.

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Posttransplant outcome of atypical haemolytic uraemic syndrome in a patient with thrombomodulin mutation: a case without recurrence.

Caroti L, Di Maria L, Carta P, Moscarelli L, Cirami C, Minetti EE.

Clin Kidney J. 2015 Jun;8(3):329-31. doi: 10.1093/ckj/sfv025. Epub 2015 Apr 27.

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Role of the skin biopsy in the diagnosis of atypical hemolytic uremic syndrome.

Magro CM, Momtahen S, Mulvey JJ, Yassin AH, Kaplan RB, Laurence JC.

Am J Dermatopathol. 2015 May;37(5):349-56; quiz 357-9. doi: 10.1097/DAD.0000000000000234.

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Atypical hemolytic uremic syndrome: from diagnosis to treatment.

Franchini M.

Clin Chem Lab Med. 2015 Oct;53(11):1679-88. doi: 10.1515/cclm-2015-0024. Review.

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Atypical hemolytic-uremic syndrome: a case report and literature review.

Rafiq A, Tariq H, Abbas N, Shenoy R.

Am J Case Rep. 2015 Feb 24;16:109-14. doi: 10.12659/AJCR.892907. Review.

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Identification and management of atypical hemolytic uremic syndrome immediately post-heart transplantation.

Vardas PN, Hashmi ZA, Hadi MA.

J Card Surg. 2015 Apr;30(4):373-5. doi: 10.1111/jocs.12520. Epub 2015 Feb 18.

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Atypical hemolytic uremic syndrome post-kidney transplantation: two case reports and review of the literature.

Alasfar S, Alachkar N.

Front Med (Lausanne). 2014 Dec 12;1:52. doi: 10.3389/fmed.2014.00052. eCollection 2014. Review.

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Current treatment of atypical hemolytic uremic syndrome.

Kaplan BS, Ruebner RL, Spinale JM, Copelovitch L.

Intractable Rare Dis Res. 2014 May;3(2):34-45. doi: 10.5582/irdr.2014.01001. Review.

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COMPLEMENTing the diagnosis of aHUS.

Afshar-Kharghan V.

Blood. 2014 Sep 11;124(11):1699-700. doi: 10.1182/blood-2014-07-590356. No abstract available.

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Hemolytic-Uremic Syndrome in childhood.

Vaisbich MH.

J Bras Nefrol. 2014 Apr-Jun;36(2):208-20. Review. English, Portuguese.

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Living kidney transplantation in adult patients with atypical haemolytic uraemic syndrome.

Verhave JC, Westra D, van Hamersvelt HW, van Helden M, van de Kar NC, Wetzels JF.

Neth J Med. 2013 Sep;71(7):342-7.

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Complement therapy in atypical haemolytic uraemic syndrome (aHUS).

Wong EK, Goodship TH, Kavanagh D.

Mol Immunol. 2013 Dec 15;56(3):199-212. doi: 10.1016/j.molimm.2013.05.224. Epub 2013 Jun 28. Review.

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Complement disorders and hemolytic uremic syndrome.

Joseph C, Gattineni J.

Curr Opin Pediatr. 2013 Apr;25(2):209-15. doi: 10.1097/MOP.0b013e32835df48a. Review.

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An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document.

Campistol JM, Arias M, Ariceta G, Blasco M, Espinosa M, Grinyó JM, Praga M, Torra R, Vilalta R, Rodríguez de Córdoba S.

Nefrologia. 2013 Jan 18;33(1):27-45. doi: 10.3265/Nefrologia.pre2012.Nov.11781. English, Spanish.

PMID: 23364625 [PubMed - indexed for MEDLINE] Free Article

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Familial atypical hemolytic uremic syndrome: a review of its genetic and clinical aspects.

Bu F, Borsa N, Gianluigi A, Smith RJ.

Clin Dev Immunol. 2012;2012:370426. doi: 10.1155/2012/370426. Epub 2012 Nov 8. Review.

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Thrombotic microangiopathy and associated renal disorders.

Barbour T, Johnson S, Cohney S, Hughes P.

Nephrol Dial Transplant. 2012 Jul;27(7):2673-85. doi: 10.1093/ndt/gfs279. Review.

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Clinical grand rounds: atypical hemolytic uremic syndrome.

Hodgkins KS, Bobrowski AE, Lane JC, Langman CB.

Am J Nephrol. 2012;35(5):394-400. doi: 10.1159/000337954. Epub 2012 Apr 18.

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A new era in the diagnosis and treatment of atypical haemolytic uraemic syndrome.

Westra D, Wetzels JF, Volokhina EB, van den Heuvel LP, van de Kar NC.

Neth J Med. 2012 Apr;70(3):121-9. Review.

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Atypical hemolytic uremic syndrome.

Loirat C, Frémeaux-Bacchi V.

Orphanet J Rare Dis. 2011 Sep 8;6:60. doi: 10.1186/1750-1172-6-60. Review.

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aHUS caused by complement dysregulation: new therapies on the horizon.

Waters AM, Licht C.

Pediatr Nephrol. 2011 Jan;26(1):41-57. doi: 10.1007/s00467-010-1556-4. Epub 2010 Jun 18. Review. Erratum in: Pediatr Nephrol. 2013 Jan;28(1):165.

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